What is Microbiome Testing and What Do Probiotics Do?

There are three integral parts to the Thryve Gut Health Program that is the key for how to improve gut health naturally and how to get rid of bad bacteria in the gut. The third of these three essential ingredients is to follow a healthy gut diet plan, which we’ll get to at the end. However, the first two will have you scratching your head and wondering, “what is microbiome testing and what do probiotics do?”

The cogs in the Thryve Gut Health Program that keep us as one of the top microbiome testing companies is our At-Home Gut Health Test Kit and personalized probiotics. Essentially, we send you everything you need to collect a sample in the privacy of your home and mail it to us for microbiome testing.
Based on the stomach bacteria in your gut biome, we formulate personalized probiotics that will help with restoring gut flora your system is lacking. As a result, you may feel relief from GI problems. Let’s take a look at the Thryve Gut Health Program, what is microbiome testing, and what do probiotics do.


Why Take a Gut Test?

Through technological advances in science, we have learned that the gut is not just the second brain. It might be the first. However, there is more to the microbiome than just the gut brain connection.

Microbes influence everything from inside-out.

Research indicates that our gut biome influences many factors in our life through a vast network of communication pathways [1].
These are known in scientific circles as:
• Digestive Tract and Healing a Leaky Gut
As you can see, your gut health affects every major function that makes us a human being. The reason for this is that poor gut health leaves the body susceptible to inflammation.


Inflammation and the Role of Gut Biome Disease

You know how Hippocrates says “All disease begins in the gut?” Modern day medicine says that inflammation is the root of all disease [2]. As you learned by reading the Ultimate Guide to the Gut-Immune-Axis, the innate immune system sets off inflammation as a response to foreign stomach bacteria and harmful microbes.

Unfortunately for those with autoimmune disease, the innate immune system also causes inflammation to attack healthy cells as well.
When we suffer from chronic inflammation, it slowly destroys a majority of our beneficial bacteria. With inflammation becoming predominant in the gut biome, these invaders alter the pH balance. This change in climate makes your gut biome a more desirable residence for harmful bacteria.


Probiotics and Inflammation

Luckily, research shows that replenishing your gut biome with probiotics may be the answer for how to get rid of bad bacteria in the gut. A few studies were conducted looking at how Lactobacillus strains interact with animal cells as well as human colon cells in vitro.


Types of Probiotics To Help Immunity

The cells were infected with Escherichia coli K88, or E.coli. Research found that one Lactobacillus strain known as Lactobacillus delbrueckii subsp. delbrueckii TUA4408L helped reverse damage caused by E.coli.
As the analysis stated,

“The activation of the MAPK and NF-κB pathways induced by E. coli 987P was downregulated via the upregulation of TLR negative regulators [3].”

Mol Nutr Food Res

TLRs are proteins that are secreted by T-Cells and B-cells in the immune system. While you appreciate these immune cells, you need them to take a chill pill sometimes. Apparently, Lactobacillus is one of those chill pills.


Types of Probiotics For Healing A Leaky Gut

Another anlaysis noted that yet an additional Lactobacillus strain exhibited anti-inflammatory effects by fighting off known biomarkers for inflammatory response.
The research paper concluded,

Lactobacillus plantarum strain CGMCC1258 has a dual effect in an IPEC-J2 model that involves epithelial permeability, the expression of inflammatory cytokines, and an abundance of tight junction proteins. In this model, the damage was induced by enterotoxigenic Escherichia coli K88. The aforementioned probiotic strain decreased the transcript levels of IL-8, tumor necrosis factor (TNF-α), and negative regulators of TLRs, such as the single Ig Il-1-related receptor (SIGIRR), B-cell CLL/lymphoma 3 (Bcl3), and mitogen-activated protein kinase phosphatase-1 (MKP-1) [2].”

Vet Immunol Immunopatho

Remember how we said inflammation is the precursor to disease? As this analysis can attest to, this includes Leaky Gut Syndrome. One of the many answers for “what do probiotics do” is they help the tight junction proteins. For those with are suffering from Leaky Gut Syndrome, long-term inflammation destroys tight junctions in the small intestines.
As a result, solid food particles and toxins seep into the gut biome, further destroying beneficial bacteria, and opening the door for harmful microbes to prosper.


Microbiome Testing for the Right Types of Probiotics

We just offered you a quick insight into how intricate the gut biome is. Just two strains of Lactobacillus bacteria can have a profound impact on your immunity and may be the answer for those who are concerned with healing a Leaky Gut.
However, what if you other gastrointestinal problems? Perhaps you’re trying to find good gut bacteria for weight loss? Others may be attempting to figure out the connection between poor gut health and depression. Whatever your incentive for wanting to know how to fix gut health naturally is, it’s as unique as you’re actual gut biome.
Your body is made of trillions of microbes. We know this because we have different eye colors, heights, food desires, GI problems, and genetics. Therefore, not just any gut health supplement will help you rebuild gut flora quickly.
In the last section, we discussed how Escherichia coli K88 was causing all the problems in the particular studies conducted. However, E.coli might be not the reason for your gastrointestinal distress or mental health issues. Perhaps it’s the antibiotic-resistant Staphylococcus aureus?. Maybe it’s a lack of Bacteroides? Whoever the perpetrator may be, you need to get to the root of the cause to find the solution. That is why you need microbiome testing.


How Does Thryve Microbiome Testing Work?


When you enroll in the Thryve Gut Health Program, we send you everything you need for success. Our At-Home Gut Test Kit comes equipped with:
At-Home Gut Health Test Kit
(courtesy: @arriagaadventures)

• A Couple of Sterile Swabs Individually Wrapped
• Vial with Preservative Liquid
• Self-Addressed and Pre-Posted Delivery Package
• Instruction Kit
• Activation Code
Once you receive your gut test kit, bring it with you into the restroom for your next bowel movement. Use one of the swabs to pick up a smear from your toilet paper and swirl that end of the swab into the vial.
Thryve Microbiome Gut Test Kit



After 20 seconds, dispose of the swab wherever you would put hazardous material. From there, place the vial in the envelope and put it into your mailbox for the next delivery.
In the meantime, get the ball rolling. Activate the number on your kit and fill out a few questions about your lifestyle choices. That way we can get the ball rolling on concocting your healthy gut diet plan. The sooner this happens, the more likely you will be to experience the maximum benefits of what do probiotics do. 


What Do Probiotics Do?

The media has been questioning the authenticity of probiotics. That’s because a study showed that a majority of gut health supplements found in drug stores are ineffective. Meanwhile, the industry continues to grow leaps and bounds. There is a reason for both of these trends. People are waking up to the fact that gut health matters. They’re just purchasing inferior products made by companies taking advantage of the “woke”.

Gut Health Test Kit


(courtesy: @momsofsacramento)

Taking a generic gut health supplement is the same thing as taking a Vitamin C tablet. If you get adequate Vitamin C in your diet, there is no need to take more in a supplement form. So, why add probiotics into your system you already have? They’re not going to help you with the gastrointestinal distress you’re feeling. You need more diversity in your gut biome.
Thanks to microbiome testing, we can pinpoint which stomach bacteria are in your gut biome. With that data, we use our groundbreaking research system that spans 4,000 microbes. We figure out which beneficial bacteria can help your body figure out how to get rid of bad bacteria in the gut.
From there, we also include beneficial strains essential for the prosperity of intestinal flora thriving in your system. However, your gut health supplements aren’t the end of your journey. If you want to experience all of what do probiotics do, you need to feed them properly.


Prebiotics for Probiotics Healthy Gut Diet Plan

The last part of the Thryve Gut Health Program is the hardest. We can do the microbiome testing and formulating personalized probiotics for you. However, we can’t force you to eat the best foods for gut health. What we can do is help you make the right choices.

Thryve Gut Health Program Dashboard

Thryve Gut Health Program Dashboard

Since we know which bad bacteria we’re trying to rid from your gut, and which beneficial bacteria we’re trying to help grow, we know which foods you should eat. Harmful bacteria like foods rich in sugar, gluten, and lactose. Instead, you want to follow a healthy gut diet plan rich in complex carbs, lean proteins, and healthy fats.


Thryve vs Other Microbiome Testing Companies

What makes Thryve different from other microbiome testing companies is that we personalize the experience every step of the way. No microbiome is the same. So, no journey toward figuring out how to get rid of bad bacteria in the gut will be the same either.

In-depth analysis of probiotics bacteria

We send you all you need for microbiome testing in a discreet manner. From there, we figure out which stomach bacteria is problematic. With that knowledge, we can tailor-make gut health supplements for your microbiome.
So, you can experience firsthand what do probiotics do, we will craft a healthy gut diet plan. These best foods for gut health will provide plenty of food for your probiotic bacteria. Plus, it will be tailored to meet your dietary preferences. Whether you are a vegan with SIBO or going Keto, we work with you to Thryve Inside.


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[1] Liang, D., Leung, R. K., Guan, W., & Au, W. W. (2018). Involvement of gut microbiome in human health and disease: brief overview, knowledge gaps and research opportunities. Gut pathogens, 10, 3. doi:10.1186/s13099-018-0230-4.
[2] Hunter P. (2012). The inflammation theory of disease. The growing realization that chronic inflammation is crucial in many diseases opens new avenues for treatment. EMBO reports, 13(11), 968–970. doi:10.1038/embor.2012.142.
[3] Wachi S., Kanmani P., Tomosada Y., Kobayashi H., Yuri T., Egusa S., Shimazu T., Suda Y., Aso H., Sugawara M., et al. Lactobacillus delbrueckii TUA4408L and its extracellular polysaccharides attenuate enterotoxigenic Escherichia coli-induced inflammatory response in porcine intestinal epitheliocytes via Toll-like receptor-2 and 4. Mol. Nutr. Food Res. 2014;58:2080–2093. doi: 10.1002/mnfr.201400218.
[4] Wu Y., Zhu C., Chen Z., Chen Z., Zhang W., Ma X., Wang L., Yang X., Jiang Z. Protective effects of Lactobacillus plantarum on epithelial barrier disruption caused by enterotoxigenic Escherichia coli in intestinal porcine epithelial cells. Vet. Immunol. Immunopathol. 2016;172:55–63. doi: 10.1016/j.vetimm.2016.03.005.

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